CovidStanfordV1, Main, Exploration, bibRecord, 000704

Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort.

Identifieur interne : 000704 ( Main/Exploration ); précédent : 000703; suivant : 000705

Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort.

Auteurs : Mette Reilev [Danemark] ; Kasper Bruun Kristensen [Danemark] ; Anton Potteg Rd [Danemark] ; Lars Christian Lund [Danemark] ; Jesper Hallas [Danemark] ; Martin Thomsen Ernst [Danemark] ; Christian Fynbo Christiansen [Danemark] ; Henrik Toft S Rensen [Danemark, États-Unis] ; Nanna Borup Johansen ; Nikolai Constantin Brun ; Marianne Voldstedlund [Danemark] ; Henrik St Vring [Danemark] ; Marianne Kragh Thomsen [Danemark] ; Steffen Christensen [Danemark] ; Sophie Gubbels [Danemark] ; Tyra Grove Krause [Danemark] ; K Re M Lbak [Danemark] ; Reimar Wernich Thomsen [Danemark]

Source :

International journal of epidemiology [ 1464-3685 ] ; 2020.

RBID : pubmed:32887982

Descripteurs français

KwdFr :
- Adulte d'âge moyen (MeSH), Cause de décès (MeSH), Comorbidité (MeSH), Danemark (épidémiologie), Facteurs de risque (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Hospitalisation (statistiques et données numériques), Humains (MeSH), Maladie chronique (épidémiologie), Mortalité (MeSH), Mâle (MeSH), Sujet âgé (MeSH).
MESH :
- statistiques et données numériques : Hospitalisation.
- épidémiologie : Danemark, Maladie chronique.
- Adulte d'âge moyen, Cause de décès, Comorbidité, Facteurs de risque, Facteurs âges, Femelle, Humains, Mortalité, Mâle, Sujet âgé.
Wicri :
- geographic : Danemark.

English descriptors

KwdEn :
- Age Factors (MeSH), Aged (MeSH), COVID-19 (mortality), COVID-19 (therapy), COVID-19 Nucleic Acid Testing (methods), COVID-19 Nucleic Acid Testing (statistics & numerical data), Cause of Death (MeSH), Chronic Disease (epidemiology), Comorbidity (MeSH), Denmark (epidemiology), Female (MeSH), Hospitalization (statistics & numerical data), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Mortality (MeSH), Risk Factors (MeSH), SARS-CoV-2 (isolation & purification).
MESH :
- geographic , epidemiology : Denmark.
- epidemiology : Chronic Disease.
- isolation & purification : SARS-CoV-2.
- methods : COVID-19 Nucleic Acid Testing.
- mortality : COVID-19.
- statistics & numerical data : COVID-19 Nucleic Acid Testing, Hospitalization.
- therapy : COVID-19.
- Age Factors, Aged, Cause of Death, Comorbidity, Female, Humans, Male, Middle Aged, Mortality, Risk Factors.

Abstract

BACKGROUND

Population-level knowledge on individuals at high risk of severe and fatal coronavirus disease 2019 (COVID-19) is urgently needed to inform targeted protection strategies in the general population.

METHODS

We examined characteristics and predictors of hospitalization and death in a nationwide cohort of all Danish individuals tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from 27 February 2020 until 19 May 2020.

RESULTS

We identified 11 122 SARS-CoV-2 polymerase chain reaction-positive cases of whom 80% were community-managed and 20% were hospitalized. Thirty-day all-cause mortality was 5.2%. Age was strongly associated with fatal disease {odds ratio [OR] 15 [95% confidence interval (CI): 9-26] for 70-79 years, increasing to OR 90 (95% CI: 50-162) for ≥90 years, when compared with cases aged 50-59 years and adjusted for sex and number of co-morbidities}. Similarly, the number of co-morbidities was associated with fatal disease [OR 5.2 (95% CI: 3.4-8.0), for cases with at least four co-morbidities vs no co-morbidities] and 79% of fatal cases had at least two co-morbidities. Most major chronic diseases were associated with hospitalization, with ORs ranging from 1.3-1.4 (e.g. stroke, ischaemic heart disease) to 2.6-3.4 (e.g. heart failure, hospital-diagnosed kidney disease, organ transplantation) and with mortality with ORs ranging from 1.1-1.3 (e.g. ischaemic heart disease, hypertension) to 2.5-3.2 (e.g. major psychiatric disorder, organ transplantation). In the absence of co-morbidities, mortality was <5% in persons aged ≤80 years.

CONCLUSIONS

In this nationwide population-based COVID-19 study, increasing age and multimorbidity were strongly associated with hospitalization and death. In the absence of co-morbidities, the mortality was, however, <5% until the age of 80 years.

DOI: 10.1093/ije/dyaa140
PubMed: 32887982
PubMed Central: PMC7499657

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000350
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Le document en format XML

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<author><name sortKey="Gubbels, Sophie" sort="Gubbels, Sophie" uniqKey="Gubbels S" first="Sophie" last="Gubbels">Sophie Gubbels</name>
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<author><name sortKey="Krause, Tyra Grove" sort="Krause, Tyra Grove" uniqKey="Krause T" first="Tyra Grove" last="Krause">Tyra Grove Krause</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort.</title>
<author><name sortKey="Reilev, Mette" sort="Reilev, Mette" uniqKey="Reilev M" first="Mette" last="Reilev">Mette Reilev</name>
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<author><name sortKey="Kristensen, Kasper Bruun" sort="Kristensen, Kasper Bruun" uniqKey="Kristensen K" first="Kasper Bruun" last="Kristensen">Kasper Bruun Kristensen</name>
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<country xml:lang="fr">Danemark</country>
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<author><name sortKey="Potteg Rd, Anton" sort="Potteg Rd, Anton" uniqKey="Potteg Rd A" first="Anton" last="Potteg Rd">Anton Potteg Rd</name>
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<country xml:lang="fr">Danemark</country>
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<affiliation wicri:level="1"><nlm:affiliation>Hospital Pharmacy Funen, Odense University Hospital, Odense, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Hospital Pharmacy Funen, Odense University Hospital, Odense</wicri:regionArea>
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<author><name sortKey="Lund, Lars Christian" sort="Lund, Lars Christian" uniqKey="Lund L" first="Lars Christian" last="Lund">Lars Christian Lund</name>
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<country xml:lang="fr">Danemark</country>
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<author><name sortKey="Hallas, Jesper" sort="Hallas, Jesper" uniqKey="Hallas J" first="Jesper" last="Hallas">Jesper Hallas</name>
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<country xml:lang="fr">Danemark</country>
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</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Biochemistry and Clinical Pharmacology, Odense University Hospital, Odense, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry and Clinical Pharmacology, Odense University Hospital, Odense</wicri:regionArea>
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<author><name sortKey="Ernst, Martin Thomsen" sort="Ernst, Martin Thomsen" uniqKey="Ernst M" first="Martin Thomsen" last="Ernst">Martin Thomsen Ernst</name>
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<author><name sortKey="Christiansen, Christian Fynbo" sort="Christiansen, Christian Fynbo" uniqKey="Christiansen C" first="Christian Fynbo" last="Christiansen">Christian Fynbo Christiansen</name>
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<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus</wicri:regionArea>
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<author><name sortKey="S Rensen, Henrik Toft" sort="S Rensen, Henrik Toft" uniqKey="S Rensen H" first="Henrik Toft" last="S Rensen">Henrik Toft S Rensen</name>
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<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Center for Population Health and Sciences, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Population Health and Sciences, Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
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</placeName>
<orgName type="university">Université Stanford</orgName>
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<author><name sortKey="Johansen, Nanna Borup" sort="Johansen, Nanna Borup" uniqKey="Johansen N" first="Nanna Borup" last="Johansen">Nanna Borup Johansen</name>
<affiliation><nlm:affiliation>Department of Medical Evaluation and Biostatistics, Danish Medicines Agency, Copenhagen, Denmark.</nlm:affiliation>
<wicri:noCountry code="subField"> Denmark</wicri:noCountry>
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<author><name sortKey="Brun, Nikolai Constantin" sort="Brun, Nikolai Constantin" uniqKey="Brun N" first="Nikolai Constantin" last="Brun">Nikolai Constantin Brun</name>
<affiliation><nlm:affiliation>Department of Medical Evaluation and Biostatistics, Danish Medicines Agency, Copenhagen, Denmark.</nlm:affiliation>
<wicri:noCountry code="subField"> Denmark</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Voldstedlund, Marianne" sort="Voldstedlund, Marianne" uniqKey="Voldstedlund M" first="Marianne" last="Voldstedlund">Marianne Voldstedlund</name>
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<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Statens Serum Institut, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
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<author><name sortKey="St Vring, Henrik" sort="St Vring, Henrik" uniqKey="St Vring H" first="Henrik" last="St Vring">Henrik St Vring</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense</wicri:regionArea>
<wicri:noRegion>Odense</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Public Health-Biostatistics, Aarhus University, Aarhus, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Public Health-Biostatistics, Aarhus University, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thomsen, Marianne Kragh" sort="Thomsen, Marianne Kragh" uniqKey="Thomsen M" first="Marianne Kragh" last="Thomsen">Marianne Kragh Thomsen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Microbiology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Christensen, Steffen" sort="Christensen, Steffen" uniqKey="Christensen S" first="Steffen" last="Christensen">Steffen Christensen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anaesthesia and Intensive Care Medicine, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Anaesthesia and Intensive Care Medicine, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gubbels, Sophie" sort="Gubbels, Sophie" uniqKey="Gubbels S" first="Sophie" last="Gubbels">Sophie Gubbels</name>
<affiliation wicri:level="3"><nlm:affiliation>Statens Serum Institut, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Statens Serum Institut, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krause, Tyra Grove" sort="Krause, Tyra Grove" uniqKey="Krause T" first="Tyra Grove" last="Krause">Tyra Grove Krause</name>
<affiliation wicri:level="3"><nlm:affiliation>Statens Serum Institut, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Statens Serum Institut, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="M Lbak, K Re" sort="M Lbak, K Re" uniqKey="M Lbak K" first="K Re" last="M Lbak">K Re M Lbak</name>
<affiliation wicri:level="3"><nlm:affiliation>Statens Serum Institut, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Statens Serum Institut, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomsen, Reimar Wernich" sort="Thomsen, Reimar Wernich" uniqKey="Thomsen R" first="Reimar Wernich" last="Thomsen">Reimar Wernich Thomsen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">International journal of epidemiology</title>
<idno type="eISSN">1464-3685</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors (MeSH)</term>
<term>Aged (MeSH)</term>
<term>COVID-19 (mortality)</term>
<term>COVID-19 (therapy)</term>
<term>COVID-19 Nucleic Acid Testing (methods)</term>
<term>COVID-19 Nucleic Acid Testing (statistics & numerical data)</term>
<term>Cause of Death (MeSH)</term>
<term>Chronic Disease (epidemiology)</term>
<term>Comorbidity (MeSH)</term>
<term>Denmark (epidemiology)</term>
<term>Female (MeSH)</term>
<term>Hospitalization (statistics & numerical data)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Mortality (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>SARS-CoV-2 (isolation & purification)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Cause de décès (MeSH)</term>
<term>Comorbidité (MeSH)</term>
<term>Danemark (épidémiologie)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Facteurs âges (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Hospitalisation (statistiques et données numériques)</term>
<term>Humains (MeSH)</term>
<term>Maladie chronique (épidémiologie)</term>
<term>Mortalité (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Denmark</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Chronic Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS-CoV-2</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>COVID-19 Nucleic Acid Testing</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>COVID-19</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>COVID-19 Nucleic Acid Testing</term>
<term>Hospitalization</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Hospitalisation</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>COVID-19</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Danemark</term>
<term>Maladie chronique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age Factors</term>
<term>Aged</term>
<term>Cause of Death</term>
<term>Comorbidity</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mortality</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Cause de décès</term>
<term>Comorbidité</term>
<term>Facteurs de risque</term>
<term>Facteurs âges</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mortalité</term>
<term>Mâle</term>
<term>Sujet âgé</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Danemark</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Population-level knowledge on individuals at high risk of severe and fatal coronavirus disease 2019 (COVID-19) is urgently needed to inform targeted protection strategies in the general population.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We examined characteristics and predictors of hospitalization and death in a nationwide cohort of all Danish individuals tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from 27 February 2020 until 19 May 2020.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>We identified 11 122 SARS-CoV-2 polymerase chain reaction-positive cases of whom 80% were community-managed and 20% were hospitalized. Thirty-day all-cause mortality was 5.2%. Age was strongly associated with fatal disease {odds ratio [OR] 15 [95% confidence interval (CI): 9-26] for 70-79 years, increasing to OR 90 (95% CI: 50-162) for ≥90 years, when compared with cases aged 50-59 years and adjusted for sex and number of co-morbidities}. Similarly, the number of co-morbidities was associated with fatal disease [OR 5.2 (95% CI: 3.4-8.0), for cases with at least four co-morbidities vs no co-morbidities] and 79% of fatal cases had at least two co-morbidities. Most major chronic diseases were associated with hospitalization, with ORs ranging from 1.3-1.4 (e.g. stroke, ischaemic heart disease) to 2.6-3.4 (e.g. heart failure, hospital-diagnosed kidney disease, organ transplantation) and with mortality with ORs ranging from 1.1-1.3 (e.g. ischaemic heart disease, hypertension) to 2.5-3.2 (e.g. major psychiatric disorder, organ transplantation). In the absence of co-morbidities, mortality was <5% in persons aged ≤80 years.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>In this nationwide population-based COVID-19 study, increasing age and multimorbidity were strongly associated with hospitalization and death. In the absence of co-morbidities, the mortality was, however, <5% until the age of 80 years.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32887982</PMID>
<DateCompleted><Year>2020</Year>
<Month>12</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2021</Year>
<Month>01</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1464-3685</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>49</Volume>
<Issue>5</Issue>
<PubDate><Year>2020</Year>
<Month>10</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>International journal of epidemiology</Title>
<ISOAbbreviation>Int J Epidemiol</ISOAbbreviation>
</Journal>
<ArticleTitle>Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort.</ArticleTitle>
<Pagination><MedlinePgn>1468-1481</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/ije/dyaa140</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Population-level knowledge on individuals at high risk of severe and fatal coronavirus disease 2019 (COVID-19) is urgently needed to inform targeted protection strategies in the general population.</AbstractText>
<AbstractText Label="METHODS">We examined characteristics and predictors of hospitalization and death in a nationwide cohort of all Danish individuals tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from 27 February 2020 until 19 May 2020.</AbstractText>
<AbstractText Label="RESULTS">We identified 11 122 SARS-CoV-2 polymerase chain reaction-positive cases of whom 80% were community-managed and 20% were hospitalized. Thirty-day all-cause mortality was 5.2%. Age was strongly associated with fatal disease {odds ratio [OR] 15 [95% confidence interval (CI): 9-26] for 70-79 years, increasing to OR 90 (95% CI: 50-162) for ≥90 years, when compared with cases aged 50-59 years and adjusted for sex and number of co-morbidities}. Similarly, the number of co-morbidities was associated with fatal disease [OR 5.2 (95% CI: 3.4-8.0), for cases with at least four co-morbidities vs no co-morbidities] and 79% of fatal cases had at least two co-morbidities. Most major chronic diseases were associated with hospitalization, with ORs ranging from 1.3-1.4 (e.g. stroke, ischaemic heart disease) to 2.6-3.4 (e.g. heart failure, hospital-diagnosed kidney disease, organ transplantation) and with mortality with ORs ranging from 1.1-1.3 (e.g. ischaemic heart disease, hypertension) to 2.5-3.2 (e.g. major psychiatric disorder, organ transplantation). In the absence of co-morbidities, mortality was <5% in persons aged ≤80 years.</AbstractText>
<AbstractText Label="CONCLUSIONS">In this nationwide population-based COVID-19 study, increasing age and multimorbidity were strongly associated with hospitalization and death. In the absence of co-morbidities, the mortality was, however, <5% until the age of 80 years.</AbstractText>
<CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Reilev</LastName>
<ForeName>Mette</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kristensen</LastName>
<ForeName>Kasper Bruun</ForeName>
<Initials>KB</Initials>
<AffiliationInfo><Affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pottegård</LastName>
<ForeName>Anton</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Hospital Pharmacy Funen, Odense University Hospital, Odense, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lund</LastName>
<ForeName>Lars Christian</ForeName>
<Initials>LC</Initials>
<AffiliationInfo><Affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hallas</LastName>
<ForeName>Jesper</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Clinical Biochemistry and Clinical Pharmacology, Odense University Hospital, Odense, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ernst</LastName>
<ForeName>Martin Thomsen</ForeName>
<Initials>MT</Initials>
<AffiliationInfo><Affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Christiansen</LastName>
<ForeName>Christian Fynbo</ForeName>
<Initials>CF</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sørensen</LastName>
<ForeName>Henrik Toft</ForeName>
<Initials>HT</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Population Health and Sciences, Stanford University, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Johansen</LastName>
<ForeName>Nanna Borup</ForeName>
<Initials>NB</Initials>
<AffiliationInfo><Affiliation>Department of Medical Evaluation and Biostatistics, Danish Medicines Agency, Copenhagen, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brun</LastName>
<ForeName>Nikolai Constantin</ForeName>
<Initials>NC</Initials>
<AffiliationInfo><Affiliation>Department of Medical Evaluation and Biostatistics, Danish Medicines Agency, Copenhagen, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Voldstedlund</LastName>
<ForeName>Marianne</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Statens Serum Institut, Copenhagen, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Støvring</LastName>
<ForeName>Henrik</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Public Health-Biostatistics, Aarhus University, Aarhus, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thomsen</LastName>
<ForeName>Marianne Kragh</ForeName>
<Initials>MK</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Christensen</LastName>
<ForeName>Steffen</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Anaesthesia and Intensive Care Medicine, Aarhus University Hospital, Aarhus, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gubbels</LastName>
<ForeName>Sophie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Statens Serum Institut, Copenhagen, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Krause</LastName>
<ForeName>Tyra Grove</ForeName>
<Initials>TG</Initials>
<AffiliationInfo><Affiliation>Statens Serum Institut, Copenhagen, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mølbak</LastName>
<ForeName>Kåre</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Statens Serum Institut, Copenhagen, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thomsen</LastName>
<ForeName>Reimar Wernich</ForeName>
<Initials>RW</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Int J Epidemiol</MedlineTA>
<NlmUniqueID>7802871</NlmUniqueID>
<ISSNLinking>0300-5771</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="Y">COVID-19</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000087123" MajorTopicYN="Y">COVID-19 Nucleic Acid Testing</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002423" MajorTopicYN="N">Cause of Death</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002908" MajorTopicYN="N">Chronic Disease</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003718" MajorTopicYN="N" Type="Geographic">Denmark</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009026" MajorTopicYN="N">Mortality</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="Y">death</Keyword>
<Keyword MajorTopicYN="Y">epidemiology</Keyword>
<Keyword MajorTopicYN="Y">hospitalization</Keyword>
<Keyword MajorTopicYN="Y">infectious disease</Keyword>
<Keyword MajorTopicYN="Y">population-based</Keyword>
<Keyword MajorTopicYN="Y">predictors</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>07</Month>
<Day>10</Day>
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<Month>9</Month>
<Day>6</Day>
<Hour>6</Hour>
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</ArticleIdList>
<ReferenceList><Reference><Citation>JAMA. 2020 Apr 28;323(16):1574-1581</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32250385</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Mar 17;323(11):1061-1069</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32031570</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Epidemiol. 2017 Jun 1;46(3):798-798f</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27789670</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Metabolism. 2020 Jul;108:154247</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32333939</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Scand J Public Health. 2011 Jul;39(7 Suppl):12-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21898916</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MMWR Morb Mortal Wkly Rep. 2020 Apr 03;69(13):382-386</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32240123</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Jun 2;323(21):2192-2195</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32347898</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 May 12;323(18):1775-1776</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32203977</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Intern Med. 2020 Aug 4;173(3):233-234</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32343767</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 May 26;323(20):2052-2059</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32320003</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Metabolism. 2020 Jul;108:154262</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32422233</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 Mar 28;395(10229):1054-1062</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32171076</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Epidemiol. 2019 Jul 12;11:563-591</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31372058</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2020 Mar 31;368:m1295</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32234718</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Epidemiol. 2015 Nov 17;7:449-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26604824</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Epidemiol. 2014 Aug;29(8):541-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24965263</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Scand J Public Health. 2011 Jul;39(7 Suppl):26-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21775346</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2013 Aug 23;347:f5061</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23974637</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Danemark</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Hovedstaden</li>
</region>
<settlement><li>Copenhague</li>
<li>Stanford (Californie)</li>
</settlement>
<orgName><li>Université Stanford</li>
</orgName>
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<tree><noCountry><name sortKey="Brun, Nikolai Constantin" sort="Brun, Nikolai Constantin" uniqKey="Brun N" first="Nikolai Constantin" last="Brun">Nikolai Constantin Brun</name>
<name sortKey="Johansen, Nanna Borup" sort="Johansen, Nanna Borup" uniqKey="Johansen N" first="Nanna Borup" last="Johansen">Nanna Borup Johansen</name>
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<country name="Danemark"><noRegion><name sortKey="Reilev, Mette" sort="Reilev, Mette" uniqKey="Reilev M" first="Mette" last="Reilev">Mette Reilev</name>
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<name sortKey="Christiansen, Christian Fynbo" sort="Christiansen, Christian Fynbo" uniqKey="Christiansen C" first="Christian Fynbo" last="Christiansen">Christian Fynbo Christiansen</name>
<name sortKey="Ernst, Martin Thomsen" sort="Ernst, Martin Thomsen" uniqKey="Ernst M" first="Martin Thomsen" last="Ernst">Martin Thomsen Ernst</name>
<name sortKey="Gubbels, Sophie" sort="Gubbels, Sophie" uniqKey="Gubbels S" first="Sophie" last="Gubbels">Sophie Gubbels</name>
<name sortKey="Hallas, Jesper" sort="Hallas, Jesper" uniqKey="Hallas J" first="Jesper" last="Hallas">Jesper Hallas</name>
<name sortKey="Hallas, Jesper" sort="Hallas, Jesper" uniqKey="Hallas J" first="Jesper" last="Hallas">Jesper Hallas</name>
<name sortKey="Krause, Tyra Grove" sort="Krause, Tyra Grove" uniqKey="Krause T" first="Tyra Grove" last="Krause">Tyra Grove Krause</name>
<name sortKey="Kristensen, Kasper Bruun" sort="Kristensen, Kasper Bruun" uniqKey="Kristensen K" first="Kasper Bruun" last="Kristensen">Kasper Bruun Kristensen</name>
<name sortKey="Lund, Lars Christian" sort="Lund, Lars Christian" uniqKey="Lund L" first="Lars Christian" last="Lund">Lars Christian Lund</name>
<name sortKey="M Lbak, K Re" sort="M Lbak, K Re" uniqKey="M Lbak K" first="K Re" last="M Lbak">K Re M Lbak</name>
<name sortKey="Potteg Rd, Anton" sort="Potteg Rd, Anton" uniqKey="Potteg Rd A" first="Anton" last="Potteg Rd">Anton Potteg Rd</name>
<name sortKey="Potteg Rd, Anton" sort="Potteg Rd, Anton" uniqKey="Potteg Rd A" first="Anton" last="Potteg Rd">Anton Potteg Rd</name>
<name sortKey="S Rensen, Henrik Toft" sort="S Rensen, Henrik Toft" uniqKey="S Rensen H" first="Henrik Toft" last="S Rensen">Henrik Toft S Rensen</name>
<name sortKey="St Vring, Henrik" sort="St Vring, Henrik" uniqKey="St Vring H" first="Henrik" last="St Vring">Henrik St Vring</name>
<name sortKey="St Vring, Henrik" sort="St Vring, Henrik" uniqKey="St Vring H" first="Henrik" last="St Vring">Henrik St Vring</name>
<name sortKey="Thomsen, Marianne Kragh" sort="Thomsen, Marianne Kragh" uniqKey="Thomsen M" first="Marianne Kragh" last="Thomsen">Marianne Kragh Thomsen</name>
<name sortKey="Thomsen, Reimar Wernich" sort="Thomsen, Reimar Wernich" uniqKey="Thomsen R" first="Reimar Wernich" last="Thomsen">Reimar Wernich Thomsen</name>
<name sortKey="Voldstedlund, Marianne" sort="Voldstedlund, Marianne" uniqKey="Voldstedlund M" first="Marianne" last="Voldstedlund">Marianne Voldstedlund</name>
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<country name="États-Unis"><region name="Californie"><name sortKey="S Rensen, Henrik Toft" sort="S Rensen, Henrik Toft" uniqKey="S Rensen H" first="Henrik Toft" last="S Rensen">Henrik Toft S Rensen</name>
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</country>
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   |texte=   Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort.
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Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort.

Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort.

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